A signaling loop of REST, TSC2 and b-catenin governs proliferation and function of PC12 neural cells
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چکیده
Romana Tomasoni*, Sara Negrini*, Stefania Fiordaliso, Andrijana Klajn, Tatiana Tkatch, Anna Mondino, Jacopo Meldolesi and Rosalba D’Alessandro Division of Immunology, Transplantation/Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, Italy Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy IIT Network, Research Unit of Molecular Neuroscience, Via Olgettina 58, 20132 Milan, Italy Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 444a Vojvode Stepe Str., PO Box 23, 11010 Belgrade, Serbia Department of Neuroscience and Brain Technologies, Italian Institute of Technology, Via Morego 30, 16163 Genova, Italy
منابع مشابه
A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells.
The RE-1-specific silencing transcription factor (REST or NRSF) is a transcription repressor that orchestrates differentiation and also operates in differentiated neurons and neurosecretory cells (neural cells). Its role in proliferation has been investigated so far only in rapidly growing tumors, with conflicting results: suppression in non-neural tumors, stimulation in medulloblastomas. Worki...
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PC12-27, a PC12 clone characterized by high levels of the transcription repressor REST and by very low mTORC2 activity, had been shown to be unresponsive to NGF, possibly because of its lack of the specific TrkA receptor. The neurotrophin receptor repressed by high REST in PC12-27 cells, however, is shown now to be not TrkA, which is normal, but p75, whose expression is inhibited at the transcr...
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PC12-27, a PC12 clone characterized by high levels of the transcription repressor REST and by very low mTORC2 activity, had been shown to be unresponsive to NGF, possibly because of its lack of the specific TrkA receptor. The neurotrophin receptor repressed by high REST in PC12-27 cells, however, is shown now to be not TrkA, which is normal, but p75(NTR), whose expression is inhibited at the tr...
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تاریخ انتشار 2011